Disaccharidase deficiency and functional bowel diseases

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Disaccharidase deficiency in man.

IT IS STILL commonly taught in physiological textbooks that carbohydrates are completely digested in the lumen of the bowel by the action of pancreatic juices and the succus entericus. This is untrue and in fact the enzymes of the succus entericus probably represent desquamated intestinal cells and are not present in sufficient quantitity to be of physiological significance, while the final sta...

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Specific Disaccharidase Deficiency in Adults

Glucose-galactose malabsorption. This rare genetically determined syndrome is at fust sight difficult to correlate with any hypothesis that there is more than one mechanism for glucose transfer, but several explanations are possible. First, in subjects with this condition the absorption of galactose is undetectable but small amounts of glucose are still absorbed (Meeuwisse & Melin, 1969). Secon...

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Microvillous surface area in secondary disaccharidase deficiency.

Electron microscopy was used to measure microvillous surface area in seven small intestinal biopsies showing secondary disaccharidase deficiency and in five biopsies having normal disaccharidase levels. There were significant reductions in microvillous surface area in the enzyme deficient group, although the microvilli were not severely damaged. Histological abnormality was not always present w...

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Disaccharidase activity in children with inflammatory bowel disease.

BACKGROUND/AIMS The etiopathogenesis of inflammatory bowel disease (IBD) is multifactorial and not well explained. Environmental, genetic, and dietary factors play an important role. The aim of the study was the evaluation of lactase, saccharase, and maltase activity in patients with IBD. MATERIALS AND METHODS The study comprised 65 children, aged 3-18 years. During a routine endoscopy, we to...

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In a recent paper on their experiences with intestinal biopsy in children with coeliac disease, Sheldon and Tempany (1966) included evidence of a reduction in disaccharidase activity in many of the biopsies, thus confirming recently published observations (Plotkin and Isselbacher, 1964; Shmerling, Auricchio, Rubino, Hadorn, and Prader, 1964; Nordio, Lamedica, Vignolo, and Berio, 1965; Lifshitz,...

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ژورنال

عنوان ژورنال: Terapevticheskii arkhiv

سال: 2017

ISSN: 2309-5342,0040-3660

DOI: 10.17116/terarkh201789445-52